Popular Brain Supplement May Shorten Men’s Lives, Study Finds

Why Tyrosine Might Influence Longevity

A new analysis of health data from more than 270,000 adults shows that men with elevated blood levels of the amino acid tyrosine—common in protein‑rich foods and many dietary supplements—tended to die earlier than those with lower levels. The research, published this week, examined participants from several European cohorts and tracked mortality over a decade, focusing on the relationship between circulating tyrosine and lifespan.

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The investigators measured tyrosine concentrations using standard blood tests and compared them with death records, adjusting for age, smoking, body mass index, and chronic disease. Men in the highest quartile of tyrosine had a 12 percent higher risk of all‑cause mortality than those in the lowest quartile. The link persisted after controlling for overall protein intake, suggesting that the amino acid itself, rather than diet quality, may play a role. Women showed no statistically significant association, highlighting a possible sex‑specific effect.

Tyrosine is a precursor for neurotransmitters such as dopamine, norepinephrine, and epinephrine, which regulate mood, stress response, and cardiovascular function. Researchers hypothesize that excess tyrosine could overstimulate these pathways, leading to chronic sympathetic activation, higher blood pressure, and accelerated wear on the heart and blood vessels. „We observed a clear gradient: the more tyrosine circulating in the bloodstream, the greater the mortality risk for men,” said Dr. Lena Hoffmann, lead author of the study. The team also noted that men who regularly used over‑the‑counter brain‑boosting supplements containing high doses of tyrosine were overrepresented among the high‑tyrosine group.

Could Cutting Tyrosine Extend Men’s Lifespans?

The findings raise the question of whether reducing tyrosine intake might improve longevity for men. While the study does not prove causation, it suggests that moderation could be prudent, especially for those taking concentrated tyrosine supplements marketed for focus and memory. Nutrition experts advise obtaining tyrosine from whole foods—such as chicken, fish, dairy, and legumes—rather than from isolated powders. „A balanced diet provides the amino acid in amounts that the body can regulate naturally,” noted dietitian Marco Silva. He cautioned against abrupt elimination, recommending gradual dietary adjustments and consultation with a healthcare professional.

The research adds to a growing body of evidence that not all popular nutraceuticals are harmless. Public health officials may consider revising guidelines for supplement labeling, emphasizing potential risks for specific populations. Future studies are needed to confirm the mechanism and explore whether similar patterns exist in other demographic groups.

Frequently Asked Questions

Is the risk limited to men who take supplements? The increased mortality risk was strongest among men with the highest blood tyrosine levels, many of whom reported regular supplement use, but high natural dietary intake also contributed.

Should women stop using tyrosine supplements? The study did not find a significant link between tyrosine levels and mortality in women, though moderation is still advisable until more data are available.

How can I check my tyrosine levels? Tyrosine can be measured through a standard blood test ordered by a physician; discuss any concerns with your healthcare provider before making changes.